Drug interactions
Fenoprofen + Tobramycin inhaled
Severity: Moderate
Fenoprofen and Tobramycin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled tobramycin has low but variable systemic absorption, and aminoglycosides can accumulate in the kidney and inner ear. NSAIDs reduce renal perfusion and may raise aminoglycoside exposure, so nephrotoxicity and ototoxicity risk may increase, especially in renal impairment.
What this interaction means in plain words
Fenoprofen and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-mediated reduction in renal blood flow and additive nephrotoxicity with aminoglycoside accumulation.
What to do
Monitor serum creatinine and tobramycin levels, and ask about hearing or balance symptoms. Avoid NSAIDs in patients with reduced renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Tobramycin inhaled?
MediHelp rates the interaction as moderate. Fenoprofen and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled tobramycin has low but variable systemic absorption, and aminoglycosides can accumulate in the kidney and inner ear. NSAIDs reduce renal perfusion and may raise aminoglycoside exposure, so nephrotoxicity and ototoxicity risk may increase, especially in renal impairment.
How serious is the interaction between Fenoprofen and Tobramycin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin levels, and ask about hearing or balance symptoms. Avoid NSAIDs in patients with reduced renal function.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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