Drug interactions
Fenoprofen + Triamcinolone acetonide injectable
Severity: Moderate
Fenoprofen and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids and NSAIDs each damage the gastroduodenal mucosa, and together the risk of peptic ulceration and gastrointestinal bleeding is higher than with either alone. Systemic exposure from injectable triamcinolone can be meaningful, particularly with repeated or large doses.
What this interaction means in plain words
Fenoprofen and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastric mucosal injury through prostaglandin inhibition by the NSAID and impaired mucosal healing from corticosteroids.
What to do
Use the lowest effective NSAID dose for the shortest time and consider gastroprotection with a proton pump inhibitor in higher-risk patients. Counsel patients to report black stools or abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Fenoprofen and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids and NSAIDs each damage the gastroduodenal mucosa, and together the risk of peptic ulceration and gastrointestinal bleeding is higher than with either alone. Systemic exposure from injectable triamcinolone can be meaningful, particularly with repeated or large doses.
How serious is the interaction between Fenoprofen and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and consider gastroprotection with a proton pump inhibitor in higher-risk patients. Counsel patients to report black stools or abdominal pain.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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