Drug interactions
Fenoprofen + Venlafaxine
Severity: Moderate
Fenoprofen and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine impairs platelet serotonin uptake and fenoprofen inhibits platelet function and damages the gastric mucosa. Together they raise the risk of bleeding, especially from the upper gastrointestinal tract.
What this interaction means in plain words
Fenoprofen and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive impairment of platelet aggregation (SNRI serotonin depletion plus NSAID COX-1 inhibition) with NSAID-related mucosal injury.
What to do
Monitor for signs of GI bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Fenoprofen with Venlafaxine?
MediHelp rates the interaction as moderate. Fenoprofen and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine impairs platelet serotonin uptake and fenoprofen inhibits platelet function and damages the gastric mucosa. Together they raise the risk of bleeding, especially from the upper gastrointestinal tract.
How serious is the interaction between Fenoprofen and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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