Drug interactions
Fentanyl + Glecaprevir / pibrentasvir
Severity: Minor
Fentanyl and Glecaprevir / pibrentasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein, which could modestly raise fentanyl exposure. The clinical effect is probably small, since fentanyl is cleared mainly by CYP3A4.
What this interaction means in plain words
Fentanyl and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
P-glycoprotein inhibition may slightly increase fentanyl absorption and reduce its efflux.
What to do
No dose change is usually needed. Be aware of increased opioid effects such as drowsiness and slow breathing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as minor. Fentanyl and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-glycoprotein, which could modestly raise fentanyl exposure. The clinical effect is probably small, since fentanyl is cleared mainly by CYP3A4.
How serious is the interaction between Fentanyl and Glecaprevir / pibrentasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Be aware of increased opioid effects such as drowsiness and slow breathing.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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