Drug interactions
Fentanyl + Indapamide
Severity: Minor
Fentanyl and Indapamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can stimulate antidiuretic hormone release and cause urinary retention, which may weaken the effect of indapamide. The effect is generally modest and variable.
What this interaction means in plain words
Fentanyl and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fentanyl belongs to Musculoskeletal; Indapamide belongs to Cardiovascular.
Why it happens
Opioid-induced antidiuretic hormone release and urinary retention may counteract diuretic effect.
What to do
Monitor blood pressure, weight and fluid status. Adjust the indapamide dose if the response is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Indapamide
Frequently asked questions
Can I take Fentanyl with Indapamide?
MediHelp rates the interaction as minor. Fentanyl and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can stimulate antidiuretic hormone release and cause urinary retention, which may weaken the effect of indapamide. The effect is generally modest and variable.
How serious is the interaction between Fentanyl and Indapamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight and fluid status. Adjust the indapamide dose if the response is reduced.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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