Drug interactions
Fentanyl + Lamotrigine
Severity: Moderate
Fentanyl and Lamotrigine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness, so together they may produce additive sedation and psychomotor impairment. The risk is greatest at initiation or with higher opioid doses.
What this interaction means in plain words
Fentanyl and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Lamotrigine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective fentanyl dose and monitor for excessive sedation. Counsel patients about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Lamotrigine
Frequently asked questions
Can I take Fentanyl with Lamotrigine?
MediHelp rates the interaction as moderate. Fentanyl and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and dizziness, so together they may produce additive sedation and psychomotor impairment. The risk is greatest at initiation or with higher opioid doses.
How serious is the interaction between Fentanyl and Lamotrigine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective fentanyl dose and monitor for excessive sedation. Counsel patients about driving and operating machinery.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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