Drug interactions
Fentanyl + Loxapine inhaled
Severity: Major
Fentanyl and Loxapine inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine is a sedating antipsychotic that adds to opioid CNS depression. The combination can cause profound sedation and respiratory depression, and inhaled loxapine can also cause bronchospasm.
What this interaction means in plain words
Fentanyl and Loxapine inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depressant effects of the antipsychotic and the opioid.
What to do
Use the lowest effective doses and monitor sedation and respiratory status, especially after loxapine inhalation. Avoid in patients with respiratory compromise.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Loxapine inhaled?
MediHelp rates the interaction as major. Fentanyl and Loxapine inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Loxapine is a sedating antipsychotic that adds to opioid CNS depression. The combination can cause profound sedation and respiratory depression, and inhaled loxapine can also cause bronchospasm.
How serious is the interaction between Fentanyl and Loxapine inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory status, especially after loxapine inhalation. Avoid in patients with respiratory compromise.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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