Drug interactions
Fentanyl + Metoclopramide intranasal
Severity: Moderate
Fentanyl and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gastric emptying and antagonize the prokinetic effect of metoclopramide, reducing its efficacy. Central nervous system effects may also be additive.
What this interaction means in plain words
Fentanyl and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opioid-mediated reduction in gastrointestinal motility opposes metoclopramide's prokinetic action; additive CNS effects.
What to do
Monitor gastric emptying response and sedation. Consider an alternative approach if symptom control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Fentanyl and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gastric emptying and antagonize the prokinetic effect of metoclopramide, reducing its efficacy. Central nervous system effects may also be additive.
How serious is the interaction between Fentanyl and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor gastric emptying response and sedation. Consider an alternative approach if symptom control is inadequate.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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