Drug interactions
Fentanyl + Mobocertinib
Severity: Moderate
Fentanyl and Mobocertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib is a moderate CYP3A inducer and may lower fentanyl concentrations. Analgesia could be reduced, and withdrawal is possible in dependent patients.
What this interaction means in plain words
Fentanyl and Mobocertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mobocertinib induces CYP3A4, increasing fentanyl metabolism.
What to do
Monitor analgesic effect and withdrawal and titrate fentanyl as needed. Reduce the dose after mobocertinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Mobocertinib?
MediHelp rates the interaction as moderate. Fentanyl and Mobocertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mobocertinib is a moderate CYP3A inducer and may lower fentanyl concentrations. Analgesia could be reduced, and withdrawal is possible in dependent patients.
How serious is the interaction between Fentanyl and Mobocertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic effect and withdrawal and titrate fentanyl as needed. Reduce the dose after mobocertinib is stopped.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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