Drug interactions
Fentanyl + Ropeginterferon alfa 2b
Severity: Moderate
Fentanyl and Ropeginterferon alfa 2b: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Interferons may suppress CYP450 enzyme activity through cytokine effects, which could reduce fentanyl metabolism and raise its concentrations. This could increase sedation and respiratory depression, though the clinical magnitude is uncertain.
What this interaction means in plain words
Fentanyl and Ropeginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytokine-mediated suppression of CYP3A4 may reduce fentanyl clearance.
What to do
Monitor for oversedation and respiratory depression after starting or increasing interferon therapy. Reduce the fentanyl dose if signs of excess opioid effect appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Ropeginterferon alfa 2b?
MediHelp rates the interaction as moderate. Fentanyl and Ropeginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Interferons may suppress CYP450 enzyme activity through cytokine effects, which could reduce fentanyl metabolism and raise its concentrations. This could increase sedation and respiratory depression, though the clinical magnitude is uncertain.
How serious is the interaction between Fentanyl and Ropeginterferon alfa 2b?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and respiratory depression after starting or increasing interferon therapy. Reduce the fentanyl dose if signs of excess opioid effect appear.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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