Drug interactions
Fentanyl + Telmisartan-amlodipine
Severity: Moderate
Fentanyl and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as fentanyl can cause hypotension, and together with an ARB and a calcium channel blocker the blood pressure-lowering effect may be additive, particularly after dosing or in volume-depleted patients. Fentanyl may also cause urinary retention.
What this interaction means in plain words
Fentanyl and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects from opioid-induced vasodilation and histamine release plus antihypertensive vasodilation and RAAS blockade.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing fentanyl in patients on this antihypertensive. Reduce the opioid dose or review the antihypertensive regimen if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Fentanyl and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids such as fentanyl can cause hypotension, and together with an ARB and a calcium channel blocker the blood pressure-lowering effect may be additive, particularly after dosing or in volume-depleted patients. Fentanyl may also cause urinary retention.
How serious is the interaction between Fentanyl and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing fentanyl in patients on this antihypertensive. Reduce the opioid dose or review the antihypertensive regimen if symptomatic hypotension occurs.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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