Drug interactions
Fentanyl + Telotristat ethyl
Severity: Moderate
Fentanyl and Telotristat ethyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat ethyl may induce CYP3A4 and lower fentanyl exposure. This could reduce analgesia, and withdrawal symptoms are possible in opioid-dependent patients.
What this interaction means in plain words
Fentanyl and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Telotristat ethyl induction of CYP3A4 increases fentanyl metabolic clearance.
What to do
Monitor pain control and titrate the fentanyl dose upward if analgesia is inadequate. Reduce the dose again if telotristat is stopped, to avoid overdose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Telotristat ethyl?
MediHelp rates the interaction as moderate. Fentanyl and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat ethyl may induce CYP3A4 and lower fentanyl exposure. This could reduce analgesia, and withdrawal symptoms are possible in opioid-dependent patients.
How serious is the interaction between Fentanyl and Telotristat ethyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and titrate the fentanyl dose upward if analgesia is inadequate. Reduce the dose again if telotristat is stopped, to avoid overdose.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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