Drug interactions
Fentanyl + Thiothixene
Severity: Moderate
Fentanyl and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics like thiothixene add sedation and hypotension to opioid effects, and may increase respiratory depression. Both can also contribute to additive effects on the CNS.
What this interaction means in plain words
Fentanyl and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and alpha-adrenergic blockade producing hypotension.
What to do
Monitor sedation, blood pressure and respiration, and begin with reduced doses. Adjust either drug if excessive sedation or hypotension appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Thiothixene?
MediHelp rates the interaction as moderate. Fentanyl and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antipsychotics like thiothixene add sedation and hypotension to opioid effects, and may increase respiratory depression. Both can also contribute to additive effects on the CNS.
How serious is the interaction between Fentanyl and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and respiration, and begin with reduced doses. Adjust either drug if excessive sedation or hypotension appears.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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