Drug interactions
Fentanyl + Tiagabine
Severity: Moderate
Fentanyl and Tiagabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tiagabine is an anticonvulsant that frequently causes dizziness and somnolence. Combined with fentanyl, the sedative effects add together and may impair alertness and breathing.
What this interaction means in plain words
Fentanyl and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through enhanced GABAergic activity and opioid effects.
What to do
Monitor for excessive sedation and respiratory depression, especially during dose changes. Counsel patients against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Tiagabine?
MediHelp rates the interaction as moderate. Fentanyl and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tiagabine is an anticonvulsant that frequently causes dizziness and somnolence. Combined with fentanyl, the sedative effects add together and may impair alertness and breathing.
How serious is the interaction between Fentanyl and Tiagabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, especially during dose changes. Counsel patients against driving and alcohol.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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