Drug interactions
Fentanyl + Triazolam
Severity: Major
Fentanyl and Triazolam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with benzodiazepines such as triazolam can cause profound sedation, respiratory depression, coma and death. This is covered by a boxed warning.
What this interaction means in plain words
Fentanyl and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression through opioid and GABA-A receptor effects.
What to do
Avoid unless alternatives are inadequate; if used, limit doses and duration and monitor respiration and sedation closely. Counsel patients and caregivers on overdose signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Triazolam?
MediHelp rates the interaction as major. Fentanyl and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with benzodiazepines such as triazolam can cause profound sedation, respiratory depression, coma and death. This is covered by a boxed warning.
How serious is the interaction between Fentanyl and Triazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless alternatives are inadequate; if used, limit doses and duration and monitor respiration and sedation closely. Counsel patients and caregivers on overdose signs.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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