Drug interactions
Fentanyl intranasal + Hydrochlorothiazide-olmesartan
Severity: Minor
Fentanyl intranasal and Hydrochlorothiazide-olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl may reduce diuretic response by promoting antidiuretic hormone release and can cause urinary retention. It can also cause hypotension that adds to the effect of the antihypertensive combination. The overall effect is usually minor.
What this interaction means in plain words
Fentanyl intranasal and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced ADH release and urinary retention oppose diuresis, while opioid vasodilation adds to the antihypertensive effect.
What to do
Monitor blood pressure, fluid balance and urine output. Adjust the antihypertensive or diuretic dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Fentanyl intranasal with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as minor. Fentanyl intranasal and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fentanyl may reduce diuretic response by promoting antidiuretic hormone release and can cause urinary retention. It can also cause hypotension that adds to the effect of the antihypertensive combination. The overall effect is usually minor.
How serious is the interaction between Fentanyl intranasal and Hydrochlorothiazide-olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid balance and urine output. Adjust the antihypertensive or diuretic dose if control changes.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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