Drug interactions
Fentanyl iontophoretic transdermal system + Pimozide
Severity: Moderate
Fentanyl iontophoretic transdermal system and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl is an opioid and pimozide is a sedating antipsychotic, so together they can increase sedation and respiratory depression and cause hypotension. Risk is greatest with higher opioid doses or other CNS depressants.
What this interaction means in plain words
Fentanyl iontophoretic transdermal system and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression.
What to do
Monitor sedation level and respiratory rate, and use the lowest effective fentanyl dose. Avoid adding other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Fentanyl iontophoretic transdermal system with Pimozide?
MediHelp rates the interaction as moderate. Fentanyl iontophoretic transdermal system and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fentanyl is an opioid and pimozide is a sedating antipsychotic, so together they can increase sedation and respiratory depression and cause hypotension. Risk is greatest with higher opioid doses or other CNS depressants.
How serious is the interaction between Fentanyl iontophoretic transdermal system and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory rate, and use the lowest effective fentanyl dose. Avoid adding other CNS depressants.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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