Drug interactions
Fentanyl iontophoretic transdermal system + Zolpidem
Severity: Major
Fentanyl iontophoretic transdermal system and Zolpidem: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with sedative-hypnotics such as zolpidem increase the risk of profound sedation, respiratory depression, coma and death. The fentanyl system is used in hospital settings, where additional sedatives may be given postoperatively.
What this interaction means in plain words
Fentanyl iontophoretic transdermal system and Zolpidem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression through opioid mu-receptor agonism and GABA-A potentiation.
What to do
Avoid combining unless necessary; if used, reduce the zolpidem dose and monitor sedation, respiratory rate and oxygen saturation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Zolpidem
Frequently asked questions
Can I take Fentanyl iontophoretic transdermal system with Zolpidem?
MediHelp rates the interaction as major. Fentanyl iontophoretic transdermal system and Zolpidem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with sedative-hypnotics such as zolpidem increase the risk of profound sedation, respiratory depression, coma and death. The fentanyl system is used in hospital settings, where additional sedatives may be given postoperatively.
How serious is the interaction between Fentanyl iontophoretic transdermal system and Zolpidem?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless necessary; if used, reduce the zolpidem dose and monitor sedation, respiratory rate and oxygen saturation.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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