Drug interactions
Fentanyl transdermal + Lamotrigine
Severity: Moderate
Fentanyl transdermal and Lamotrigine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lamotrigine can cause drowsiness and dizziness, and fentanyl is a potent opioid that causes sedation and respiratory depression. Together they may produce greater sedation and impaired alertness than either drug alone.
What this interaction means in plain words
Fentanyl transdermal and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression.
What to do
Monitor sedation level and respiratory rate, particularly during initiation and dose titration. Use the lowest effective opioid dose and warn the patient about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Frequently asked questions
Can I take Fentanyl transdermal with Lamotrigine?
MediHelp rates the interaction as moderate. Fentanyl transdermal and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lamotrigine can cause drowsiness and dizziness, and fentanyl is a potent opioid that causes sedation and respiratory depression. Together they may produce greater sedation and impaired alertness than either drug alone.
How serious is the interaction between Fentanyl transdermal and Lamotrigine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory rate, particularly during initiation and dose titration. Use the lowest effective opioid dose and warn the patient about driving and alcohol.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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