Drug interactions
Ferrous fumarate + Ibuprofen / famotidine
Severity: Moderate
Ferrous fumarate and Ibuprofen / famotidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine reduces gastric acid, and oral iron needs an acidic environment for good absorption. Prolonged use together may lower iron uptake and reduce the effect of iron therapy.
What this interaction means in plain words
Ferrous fumarate and Ibuprofen / famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Famotidine-induced increase in gastric pH reduces iron solubility and absorption.
What to do
Monitor hemoglobin and ferritin during prolonged co-use. Adjust the iron dose or switch route if the response is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ferrous fumarate
Frequently asked questions
Can I take Ferrous fumarate with Ibuprofen / famotidine?
MediHelp rates the interaction as moderate. Ferrous fumarate and Ibuprofen / famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Famotidine reduces gastric acid, and oral iron needs an acidic environment for good absorption. Prolonged use together may lower iron uptake and reduce the effect of iron therapy.
How serious is the interaction between Ferrous fumarate and Ibuprofen / famotidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and ferritin during prolonged co-use. Adjust the iron dose or switch route if the response is poor.
What other medicines interact with Ferrous fumarate?
MediHelp also lists interactions of Ferrous fumarate with, for example, Ciprofloxacin, Acetohydroxamic acid, Aluminum hydroxide. The full list is on the Ferrous fumarate page.
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