Drug interactions
Ferrous fumarate + Lansoprazole
Severity: Moderate
Ferrous fumarate and Lansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-heme oral iron absorption depends on gastric acid, so lansoprazole can reduce iron uptake. With long-term use this may reduce response to iron replacement.
What this interaction means in plain words
Ferrous fumarate and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ferrous fumarate belongs to Miscellaneous; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Reduced gastric acid impairs solubilization and reduction of ferric to ferrous iron.
What to do
Monitor hemoglobin and ferritin, and consider a higher iron dose, alternate-day dosing, or IV iron if response is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Ferrous fumarate
Frequently asked questions
Can I take Ferrous fumarate with Lansoprazole?
MediHelp rates the interaction as moderate. Ferrous fumarate and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-heme oral iron absorption depends on gastric acid, so lansoprazole can reduce iron uptake. With long-term use this may reduce response to iron replacement.
How serious is the interaction between Ferrous fumarate and Lansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and ferritin, and consider a higher iron dose, alternate-day dosing, or IV iron if response is poor.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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