Drug interactions
Ferrous sulfate + Rabeprazole
Severity: Moderate
Ferrous sulfate and Rabeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reduced gastric acidity decreases absorption of oral ferrous sulfate. Long-term PPI use may blunt response to oral iron therapy.
What this interaction means in plain words
Ferrous sulfate and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ferrous sulfate belongs to Miscellaneous; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces iron solubility and absorption.
What to do
Monitor hemoglobin and ferritin; consider parenteral iron or reassess the need for the PPI if iron stores do not improve.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Ferrous sulfate
Frequently asked questions
Can I take Ferrous sulfate with Rabeprazole?
MediHelp rates the interaction as moderate. Ferrous sulfate and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Reduced gastric acidity decreases absorption of oral ferrous sulfate. Long-term PPI use may blunt response to oral iron therapy.
How serious is the interaction between Ferrous sulfate and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and ferritin; consider parenteral iron or reassess the need for the PPI if iron stores do not improve.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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