Drug interactions
Feverfew + Ketorolac
Severity: Moderate
Feverfew and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Feverfew inhibits platelet aggregation in laboratory studies and may add to the antiplatelet effect of ketorolac, increasing bleeding tendency. Clinical reports are limited.
What this interaction means in plain words
Feverfew and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Parthenolide-related constituents of feverfew inhibit platelet function, adding to ketorolac's cyclooxygenase-mediated platelet inhibition.
What to do
Advise patients to avoid feverfew during ketorolac treatment and monitor for bleeding if both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Feverfew with Ketorolac?
MediHelp rates the interaction as moderate. Feverfew and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Feverfew inhibits platelet aggregation in laboratory studies and may add to the antiplatelet effect of ketorolac, increasing bleeding tendency. Clinical reports are limited.
How serious is the interaction between Feverfew and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid feverfew during ketorolac treatment and monitor for bleeding if both are used.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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