Drug interactions
Fexinidazole + Fluticasone furoate
Severity: Moderate
Fexinidazole and Fluticasone furoate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4, which may increase systemic exposure to fluticasone furoate. Higher exposure can cause systemic corticosteroid effects such as adrenal suppression and Cushingoid features, particularly with prolonged use.
What this interaction means in plain words
Fexinidazole and Fluticasone furoate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition reduces the metabolic clearance of fluticasone furoate.
What to do
Fexinidazole is given for a short course, so monitor for corticosteroid systemic effects. Consider a less CYP3A4-dependent corticosteroid if prolonged co-therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Fexinidazole with Fluticasone furoate?
MediHelp rates the interaction as moderate. Fexinidazole and Fluticasone furoate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole inhibits CYP3A4, which may increase systemic exposure to fluticasone furoate. Higher exposure can cause systemic corticosteroid effects such as adrenal suppression and Cushingoid features, particularly with prolonged use.
How serious is the interaction between Fexinidazole and Fluticasone furoate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Fexinidazole is given for a short course, so monitor for corticosteroid systemic effects. Consider a less CYP3A4-dependent corticosteroid if prolonged co-therapy is needed.
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