Drug interactions
Fexinidazole + Lansoprazole
Severity: Minor
Fexinidazole and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and so raise lansoprazole concentrations, which are partly cleared by this enzyme. Lansoprazole has a wide safety margin, so the effect is generally modest.
What this interaction means in plain words
Fexinidazole and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 by fexinidazole reduces the sulfoxidation of lansoprazole.
What to do
No routine adjustment is needed during the short fexinidazole course; watch for PPI adverse effects such as headache or diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Fexinidazole with Lansoprazole?
MediHelp rates the interaction as minor. Fexinidazole and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fexinidazole may inhibit CYP3A4 and so raise lansoprazole concentrations, which are partly cleared by this enzyme. Lansoprazole has a wide safety margin, so the effect is generally modest.
How serious is the interaction between Fexinidazole and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed during the short fexinidazole course; watch for PPI adverse effects such as headache or diarrhea.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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