Drug interactions
Fexinidazole + Pimozide
Severity: Contraindicated
Fexinidazole and Pimozide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole prolongs the QT interval and inhibits CYP3A4, which raises pimozide exposure. Together these effects increase the risk of torsades de pointes.
What this interaction means in plain words
Fexinidazole and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive QTc prolongation plus CYP3A4 inhibition by fexinidazole.
What to do
Do not coadminister; withhold pimozide or use an alternative. If exposure occurs, monitor ECG and electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Fexinidazole with Pimozide?
MediHelp rates the interaction as contraindicated. Fexinidazole and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fexinidazole prolongs the QT interval and inhibits CYP3A4, which raises pimozide exposure. Together these effects increase the risk of torsades de pointes.
How serious is the interaction between Fexinidazole and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; withhold pimozide or use an alternative. If exposure occurs, monitor ECG and electrolytes.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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