Drug interactions
Fexinidazole + Rabeprazole
Severity: Minor
Fexinidazole and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rabeprazole is mostly cleared non-enzymatically with limited CYP3A4 involvement, so fexinidazole inhibition has little effect. Clinical impact is unlikely.
What this interaction means in plain words
Fexinidazole and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Minor CYP3A4 inhibition by fexinidazole with limited contribution to rabeprazole clearance.
What to do
No adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Fexinidazole with Rabeprazole?
MediHelp rates the interaction as minor. Fexinidazole and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rabeprazole is mostly cleared non-enzymatically with limited CYP3A4 involvement, so fexinidazole inhibition has little effect. Clinical impact is unlikely.
How serious is the interaction between Fexinidazole and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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