Drug interactions
Fexinidazole + Sildenafil
Severity: Moderate
Fexinidazole and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and raise sildenafil concentrations. This could increase hypotension, headache, visual disturbance and other dose-related adverse effects.
What this interaction means in plain words
Fexinidazole and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole and its metabolites inhibit CYP3A4, reducing sildenafil clearance.
What to do
Use the lowest effective sildenafil dose, such as 25 mg for erectile dysfunction, and monitor blood pressure and tolerability. Avoid use for pulmonary hypertension if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Frequently asked questions
Can I take Fexinidazole with Sildenafil?
MediHelp rates the interaction as moderate. Fexinidazole and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and raise sildenafil concentrations. This could increase hypotension, headache, visual disturbance and other dose-related adverse effects.
How serious is the interaction between Fexinidazole and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective sildenafil dose, such as 25 mg for erectile dysfunction, and monitor blood pressure and tolerability. Avoid use for pulmonary hypertension if possible.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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