Drug interactions
Fexinidazole + Theophylline
Severity: Moderate
Fexinidazole and Theophylline: moderate interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP enzymes and could raise theophylline exposure. Since theophylline has a narrow therapeutic range, even modest increases could cause tremor, tachycardia, arrhythmia or seizures. The clinical size of the effect is not well characterised.
What this interaction means in plain words
Fexinidazole and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole and its metabolites inhibit CYP enzymes including CYP3A4, which may reduce theophylline clearance.
What to do
Monitor theophylline serum concentrations and signs of toxicity during fexinidazole treatment, and reduce the theophylline dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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References
- Fexinidazole - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Frequently asked questions
Can I take Fexinidazole with Theophylline?
MediHelp rates the interaction as moderate. Fexinidazole and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP enzymes and could raise theophylline exposure. Since theophylline has a narrow therapeutic range, even modest increases could cause tremor, tachycardia, arrhythmia or seizures. The clinical size of the effect is not well characterised.
How serious is the interaction between Fexinidazole and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline serum concentrations and signs of toxicity during fexinidazole treatment, and reduce the theophylline dose if levels rise.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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