Drug interactions
Fexinidazole + Tofacitinib
Severity: Moderate
Fexinidazole and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and could increase tofacitinib exposure, raising the risk of infection and cytopenias. The clinical data are limited.
What this interaction means in plain words
Fexinidazole and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole is reported to inhibit CYP3A4, which may reduce tofacitinib clearance.
What to do
Consider reducing the tofacitinib dose during the short fexinidazole course, as for CYP3A4 inhibitors. Monitor for infection and blood count changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Frequently asked questions
Can I take Fexinidazole with Tofacitinib?
MediHelp rates the interaction as moderate. Fexinidazole and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and could increase tofacitinib exposure, raising the risk of infection and cytopenias. The clinical data are limited.
How serious is the interaction between Fexinidazole and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the tofacitinib dose during the short fexinidazole course, as for CYP3A4 inhibitors. Monitor for infection and blood count changes.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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