Drug interactions
Fexinidazole + Ulipristal
Severity: Moderate
Fexinidazole and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its metabolites may inhibit CYP3A4, which could increase ulipristal exposure. The clinical importance is uncertain and based largely on prediction.
What this interaction means in plain words
Fexinidazole and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, reducing ulipristal metabolism.
What to do
Consider a copper intrauterine device or levonorgestrel instead. If ulipristal is used, counsel on possible increased adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fexinidazole and Ulipristal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Frequently asked questions
Can I take Fexinidazole with Ulipristal?
MediHelp rates the interaction as moderate. Fexinidazole and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its metabolites may inhibit CYP3A4, which could increase ulipristal exposure. The clinical importance is uncertain and based largely on prediction.
How serious is the interaction between Fexinidazole and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a copper intrauterine device or levonorgestrel instead. If ulipristal is used, counsel on possible increased adverse effects.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
