Drug interactions
Fexinidazole + Zolpidem
Severity: Moderate
Fexinidazole and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may raise zolpidem exposure, intensifying sedation, next-day impairment and complex sleep behaviours. The effect is predicted from CYP3A4 inhibition rather than well characterised clinically.
What this interaction means in plain words
Fexinidazole and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated zolpidem metabolism by fexinidazole or its metabolites.
What to do
Consider a lower zolpidem dose or an alternative hypnotic during fexinidazole treatment, and monitor for excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Frequently asked questions
Can I take Fexinidazole with Zolpidem?
MediHelp rates the interaction as moderate. Fexinidazole and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may raise zolpidem exposure, intensifying sedation, next-day impairment and complex sleep behaviours. The effect is predicted from CYP3A4 inhibition rather than well characterised clinically.
How serious is the interaction between Fexinidazole and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower zolpidem dose or an alternative hypnotic during fexinidazole treatment, and monitor for excessive sedation.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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