Drug interactions
Fish oil triglycerides + Ketorolac
Severity: Moderate
Fish oil triglycerides and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omega-3 fatty acids can modestly impair platelet aggregation and prolong bleeding time. Combined with ketorolac, which strongly inhibits platelet function and irritates the gastric mucosa, the chance of bleeding may increase.
What this interaction means in plain words
Fish oil triglycerides and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects: ketorolac inhibits COX-1-mediated thromboxane formation while omega-3 fatty acids alter platelet function.
What to do
Watch for signs of bleeding, especially gastrointestinal, and keep ketorolac courses short. Reassess the need for fish oil in patients with other bleeding risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Fish oil triglycerides with Ketorolac?
MediHelp rates the interaction as moderate. Fish oil triglycerides and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omega-3 fatty acids can modestly impair platelet aggregation and prolong bleeding time. Combined with ketorolac, which strongly inhibits platelet function and irritates the gastric mucosa, the chance of bleeding may increase.
How serious is the interaction between Fish oil triglycerides and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of bleeding, especially gastrointestinal, and keep ketorolac courses short. Reassess the need for fish oil in patients with other bleeding risk factors.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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