Drug interactions
Fleroxacin + Glibenclamide
Severity: Moderate
Fleroxacin and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia, and the risk is highest in diabetic patients taking sulfonylureas. Severe hypoglycemia, sometimes with coma, has been reported with this class.
What this interaction means in plain words
Fleroxacin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluoroquinolones may stimulate pancreatic insulin release by blocking beta-cell potassium channels, adding to the effect of glyburide.
What to do
Monitor blood glucose closely during the antibiotic course and warn patients about hypoglycemia symptoms. Consider a different antibiotic class in high-risk patients such as the elderly or those with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Fleroxacin with Glibenclamide?
MediHelp rates the interaction as moderate. Fleroxacin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia, and the risk is highest in diabetic patients taking sulfonylureas. Severe hypoglycemia, sometimes with coma, has been reported with this class.
How serious is the interaction between Fleroxacin and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the antibiotic course and warn patients about hypoglycemia symptoms. Consider a different antibiotic class in high-risk patients such as the elderly or those with renal impairment.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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