Drug interactions
Fleroxacin + Insulin aspart
Severity: Moderate
Fleroxacin and Insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients receiving insulin. Severe, occasionally fatal hypoglycemia has been reported with this class. Fleroxacin is not widely marketed.
What this interaction means in plain words
Fleroxacin and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluoroquinolones can alter pancreatic beta-cell insulin release through potassium channel effects, causing dysglycemia.
What to do
Monitor blood glucose closely during and after therapy, and adjust the insulin dose accordingly. Switch to a non-quinolone antibiotic if dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Frequently asked questions
Can I take Fleroxacin with Insulin aspart?
MediHelp rates the interaction as moderate. Fleroxacin and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients receiving insulin. Severe, occasionally fatal hypoglycemia has been reported with this class. Fleroxacin is not widely marketed.
How serious is the interaction between Fleroxacin and Insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and after therapy, and adjust the insulin dose accordingly. Switch to a non-quinolone antibiotic if dysglycemia occurs.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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