Drug interactions
Fleroxacin + Metformin
Severity: Moderate
Fleroxacin and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia, especially in diabetic patients on glucose-lowering drugs. Severe dysglycemia has been reported with this class.
What this interaction means in plain words
Fleroxacin and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluoroquinolone effects on pancreatic beta-cell insulin release cause unpredictable dysglycemia.
What to do
Monitor blood glucose closely during fluoroquinolone therapy and counsel the patient on symptoms of hypo- and hyperglycemia. Consider an alternative antibiotic if dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Frequently asked questions
Can I take Fleroxacin with Metformin?
MediHelp rates the interaction as moderate. Fleroxacin and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia, especially in diabetic patients on glucose-lowering drugs. Severe dysglycemia has been reported with this class.
How serious is the interaction between Fleroxacin and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during fluoroquinolone therapy and counsel the patient on symptoms of hypo- and hyperglycemia. Consider an alternative antibiotic if dysglycemia occurs.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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