Drug interactions
Fluorouracil + Glibenclamide
Severity: Minor
Fluorouracil and Glibenclamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluorouracil may reduce CYP2C9-mediated clearance of some drugs, which could raise glyburide exposure and the risk of hypoglycemia. The evidence is limited and mostly extrapolated from effects on other CYP2C9 substrates such as warfarin and phenytoin. Glyburide is also metabolized by other routes, which limits the likely impact.
What this interaction means in plain words
Fluorouracil and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluorouracil belongs to Oncology; Glibenclamide belongs to Endocrine.
Why it happens
Possible inhibition of CYP2C9 metabolism of glyburide by fluorouracil; not firmly established for this pair.
What to do
Monitor blood glucose during fluorouracil courses and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Fluorouracil
Frequently asked questions
Can I take Fluorouracil with Glibenclamide?
MediHelp rates the interaction as minor. Fluorouracil and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluorouracil may reduce CYP2C9-mediated clearance of some drugs, which could raise glyburide exposure and the risk of hypoglycemia. The evidence is limited and mostly extrapolated from effects on other CYP2C9 substrates such as warfarin and phenytoin. Glyburide is also metabolized by other routes, which limits the likely impact.
How serious is the interaction between Fluorouracil and Glibenclamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during fluorouracil courses and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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