Drug interactions
Fluorouracil + Temoporfin
Severity: Moderate
Fluorouracil and Temoporfin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temoporfin causes prolonged skin photosensitivity, and topical fluorouracil can also increase photosensitivity. Together they may worsen phototoxic skin reactions.
What this interaction means in plain words
Fluorouracil and Temoporfin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluorouracil belongs to Oncology; Temoporfin belongs to Oncology.
Why it happens
Additive photosensitising effects on the skin.
What to do
Avoid topical fluorouracil on exposed skin around the time of temoporfin photosensitivity, and keep strict light protection. Review skin for phototoxic reactions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluorouracil
Frequently asked questions
Can I take Fluorouracil with Temoporfin?
MediHelp rates the interaction as moderate. Fluorouracil and Temoporfin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temoporfin causes prolonged skin photosensitivity, and topical fluorouracil can also increase photosensitivity. Together they may worsen phototoxic skin reactions.
How serious is the interaction between Fluorouracil and Temoporfin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid topical fluorouracil on exposed skin around the time of temoporfin photosensitivity, and keep strict light protection. Review skin for phototoxic reactions.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Fluorouracil page.
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