Drug interactions
Flurazepam + Ketamine
Severity: Moderate
Flurazepam and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting benzodiazepine hypnotic, and its active metabolites persist for days. With ketamine it can add to sedation and respiratory depression, particularly in older adults.
What this interaction means in plain words
Flurazepam and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and NMDA antagonism.
What to do
Monitor sedation and respiration, and use reduced doses in elderly or frail patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Frequently asked questions
Can I take Flurazepam with Ketamine?
MediHelp rates the interaction as moderate. Flurazepam and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting benzodiazepine hypnotic, and its active metabolites persist for days. With ketamine it can add to sedation and respiratory depression, particularly in older adults.
How serious is the interaction between Flurazepam and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiration, and use reduced doses in elderly or frail patients.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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