Drug interactions
Flurazepam + Olanzapine
Severity: Moderate
Flurazepam and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting benzodiazepine hypnotic with an active metabolite, and olanzapine is sedating. Together they increase daytime drowsiness, falls and psychomotor impairment, with possible cardiorespiratory depression.
What this interaction means in plain words
Flurazepam and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective doses and monitor sedation and orthostatic blood pressure. Prefer a shorter-acting hypnotic in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Flurazepam with Olanzapine?
MediHelp rates the interaction as moderate. Flurazepam and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting benzodiazepine hypnotic with an active metabolite, and olanzapine is sedating. Together they increase daytime drowsiness, falls and psychomotor impairment, with possible cardiorespiratory depression.
How serious is the interaction between Flurazepam and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and orthostatic blood pressure. Prefer a shorter-acting hypnotic in older patients.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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