Drug interactions
Flurazepam + Pimozide
Severity: Moderate
Flurazepam and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam and pimozide both cause CNS depression, so the combination increases drowsiness, impaired psychomotor performance and fall risk. Flurazepam's long-acting active metabolite prolongs this effect, especially in older adults.
What this interaction means in plain words
Flurazepam and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and dopamine/histamine receptor blockade.
What to do
Use the lowest effective doses and consider a shorter-acting hypnotic in older patients. Counsel about driving and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Flurazepam with Pimozide?
MediHelp rates the interaction as moderate. Flurazepam and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam and pimozide both cause CNS depression, so the combination increases drowsiness, impaired psychomotor performance and fall risk. Flurazepam's long-acting active metabolite prolongs this effect, especially in older adults.
How serious is the interaction between Flurazepam and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and consider a shorter-acting hypnotic in older patients. Counsel about driving and falls.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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