Drug interactions
Flurazepam + Triprolidine
Severity: Moderate
Flurazepam and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting benzodiazepine hypnotic with an active metabolite that persists for days. Combined with triprolidine, sedation, psychomotor impairment and falls risk may increase, especially in older adults.
What this interaction means in plain words
Flurazepam and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and H1 blockade.
What to do
Monitor for daytime sedation and falls, and use a lower flurazepam dose in the elderly. Avoid alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Frequently asked questions
Can I take Flurazepam with Triprolidine?
MediHelp rates the interaction as moderate. Flurazepam and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting benzodiazepine hypnotic with an active metabolite that persists for days. Combined with triprolidine, sedation, psychomotor impairment and falls risk may increase, especially in older adults.
How serious is the interaction between Flurazepam and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for daytime sedation and falls, and use a lower flurazepam dose in the elderly. Avoid alcohol and driving.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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