Drug interactions
Flurazepam + Zolpidem
Severity: Major
Flurazepam and Zolpidem: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are GABA-A positive modulators hypnotics, and flurazepam has long-acting active metabolites. Together they increase sedation, next-day impairment, falls and respiratory depression risk.
What this interaction means in plain words
Flurazepam and Zolpidem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression via GABA-A receptor modulation.
What to do
Avoid using two hypnotics together. If necessary, use the lowest doses and monitor sedation and respiration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Zolpidem
Frequently asked questions
Can I take Flurazepam with Zolpidem?
MediHelp rates the interaction as major. Flurazepam and Zolpidem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are GABA-A positive modulators hypnotics, and flurazepam has long-acting active metabolites. Together they increase sedation, next-day impairment, falls and respiratory depression risk.
How serious is the interaction between Flurazepam and Zolpidem?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two hypnotics together. If necessary, use the lowest doses and monitor sedation and respiration.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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