Drug interactions
Fluticasone furoate + Fosamprenavir
Severity: Moderate
Fluticasone furoate and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir (amprenavir), especially when ritonavir-boosted, inhibits CYP3A4 and raises systemic fluticasone levels. Prolonged use can lead to adrenal suppression and Cushing syndrome.
What this interaction means in plain words
Fluticasone furoate and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amprenavir inhibits CYP3A4, reducing fluticasone clearance.
What to do
Consider switching to beclomethasone for long-term therapy. Otherwise monitor for Cushingoid features and adrenal suppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Fluticasone furoate with Fosamprenavir?
MediHelp rates the interaction as moderate. Fluticasone furoate and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir (amprenavir), especially when ritonavir-boosted, inhibits CYP3A4 and raises systemic fluticasone levels. Prolonged use can lead to adrenal suppression and Cushing syndrome.
How serious is the interaction between Fluticasone furoate and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider switching to beclomethasone for long-term therapy. Otherwise monitor for Cushingoid features and adrenal suppression.
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