Drug interactions
Fluticasone furoate + Fosphenytoin
Severity: Minor
Fluticasone furoate and Fosphenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosphenytoin induces CYP3A4 and may lower systemic exposure to fluticasone furoate. With inhaled or intranasal use the effect is usually small, but local anti-inflammatory control could be reduced in some patients.
What this interaction means in plain words
Fluticasone furoate and Fosphenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Phenytoin (the active form of fosphenytoin) induces hepatic and intestinal CYP3A4, increasing fluticasone clearance.
What to do
Monitor asthma or rhinitis control and increase the corticosteroid dose or choose an alternative if symptoms worsen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Fluticasone furoate with Fosphenytoin?
MediHelp rates the interaction as minor. Fluticasone furoate and Fosphenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosphenytoin induces CYP3A4 and may lower systemic exposure to fluticasone furoate. With inhaled or intranasal use the effect is usually small, but local anti-inflammatory control could be reduced in some patients.
How serious is the interaction between Fluticasone furoate and Fosphenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma or rhinitis control and increase the corticosteroid dose or choose an alternative if symptoms worsen.
What other medicines interact with Fosphenytoin?
MediHelp also lists interactions of Fosphenytoin with, for example, Dronedarone, Ledipasvir-sofosbuvir, Lorlatinib. The full list is on the Fosphenytoin page.
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