Drug interactions
Fluticasone furoate + Grapefruit
Severity: Minor
Fluticasone furoate and Grapefruit: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice may inhibit intestinal CYP3A4 and slightly raise fluticasone furoate exposure. Because inhaled and intranasal bioavailability is low and the effect is modest, clinical significance is limited.
What this interaction means in plain words
Fluticasone furoate and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Furanocoumarins in grapefruit inhibit intestinal CYP3A4, reducing first-pass metabolism of swallowed fluticasone.
What to do
No routine action is needed; counsel patients on long-term high-dose therapy to avoid large regular amounts of grapefruit juice.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Frequently asked questions
Can I take Fluticasone furoate with Grapefruit?
MediHelp rates the interaction as minor. Fluticasone furoate and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice may inhibit intestinal CYP3A4 and slightly raise fluticasone furoate exposure. Because inhaled and intranasal bioavailability is low and the effect is modest, clinical significance is limited.
How serious is the interaction between Fluticasone furoate and Grapefruit?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; counsel patients on long-term high-dose therapy to avoid large regular amounts of grapefruit juice.
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