Drug interactions
Fluticasone furoate + Indinavir
Severity: Moderate
Fluticasone furoate and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may increase systemic exposure to fluticasone furoate, raising the risk of systemic corticosteroid effects. The risk increases with long-term use.
What this interaction means in plain words
Fluticasone furoate and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4-mediated metabolism of fluticasone.
What to do
Monitor for Cushingoid features and adrenal suppression, or switch to a corticosteroid less dependent on CYP3A4 such as beclomethasone for long-term therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Fluticasone furoate with Indinavir?
MediHelp rates the interaction as moderate. Fluticasone furoate and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and may increase systemic exposure to fluticasone furoate, raising the risk of systemic corticosteroid effects. The risk increases with long-term use.
How serious is the interaction between Fluticasone furoate and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for Cushingoid features and adrenal suppression, or switch to a corticosteroid less dependent on CYP3A4 such as beclomethasone for long-term therapy.
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