Drug interactions
Fluticasone furoate + Isoniazid
Severity: Minor
Fluticasone furoate and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid has weak, variable CYP3A4 inhibitory activity, so a meaningful rise in fluticasone furoate exposure is unlikely at inhaled doses. Any effect would be small and of limited clinical relevance.
What this interaction means in plain words
Fluticasone furoate and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak inhibition of CYP3A4 by isoniazid reducing fluticasone clearance; not firmly established.
What to do
No routine action is needed. Be alert for signs of systemic corticosteroid excess if symptoms arise during long-term co-use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Fluticasone furoate with Isoniazid?
MediHelp rates the interaction as minor. Fluticasone furoate and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid has weak, variable CYP3A4 inhibitory activity, so a meaningful rise in fluticasone furoate exposure is unlikely at inhaled doses. Any effect would be small and of limited clinical relevance.
How serious is the interaction between Fluticasone furoate and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Be alert for signs of systemic corticosteroid excess if symptoms arise during long-term co-use.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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