Drug interactions
Fluticasone furoate + Nefazodone
Severity: Moderate
Fluticasone furoate and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and may raise systemic fluticasone furoate exposure. This could cause systemic corticosteroid effects with prolonged use.
What this interaction means in plain words
Fluticasone furoate and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nefazodone inhibits CYP3A4, decreasing fluticasone metabolism.
What to do
Monitor for corticosteroid excess with long-term co-use, or choose beclomethasone or another alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Fluticasone furoate with Nefazodone?
MediHelp rates the interaction as moderate. Fluticasone furoate and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a strong CYP3A4 inhibitor and may raise systemic fluticasone furoate exposure. This could cause systemic corticosteroid effects with prolonged use.
How serious is the interaction between Fluticasone furoate and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess with long-term co-use, or choose beclomethasone or another alternative.
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