Drug interactions
Fluticasone furoate + Nirmatrelvir
Severity: Moderate
Fluticasone furoate and Nirmatrelvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nirmatrelvir is a CYP3A4 inhibitor that can increase fluticasone furoate exposure. Over a short 5-day course the risk of systemic effects is low, but it increases with prolonged co-administration.
What this interaction means in plain words
Fluticasone furoate and Nirmatrelvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nirmatrelvir inhibits CYP3A4, reducing fluticasone clearance.
What to do
For a short course, continue therapy and monitor; if prolonged use is expected, consider beclomethasone or prednisolone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nirmatrelvir
- Alfuzosin + Nirmatrelvir Contraindicated
- Amiodarone + Nirmatrelvir Contraindicated
- Apalutamide + Nirmatrelvir Contraindicated
- Carbamazepine + Nirmatrelvir Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
- Dronedarone + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Fluticasone furoate with Nirmatrelvir?
MediHelp rates the interaction as moderate. Fluticasone furoate and Nirmatrelvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nirmatrelvir is a CYP3A4 inhibitor that can increase fluticasone furoate exposure. Over a short 5-day course the risk of systemic effects is low, but it increases with prolonged co-administration.
How serious is the interaction between Fluticasone furoate and Nirmatrelvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For a short course, continue therapy and monitor; if prolonged use is expected, consider beclomethasone or prednisolone.
What other medicines interact with Nirmatrelvir?
MediHelp also lists interactions of Nirmatrelvir with, for example, Alfuzosin, Amiodarone, Apalutamide. The full list is on the Nirmatrelvir page.
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